| Edition |
4th ed |
| Description |
xviii, 375 pages : illustrations (some color) ; 25 cm. |
| Bibliography |
Includes bibliographical references and index. |
| Contents |
1 Introduction -- 1.1 What is cancer? -- 1.2 Evidence suggests that cancer is a disease of the genome at cellular level -- 1.3 Influential factors in human carcinogenesis -- 1.4 Principles of conventional cancer therapies -- 1.5 Clinical trials -- 1.6 The role of molecular targets in cancer therapies -- 2 DNA structure and stability: mutations versus repair -- 2.1 Gene structure -- two parts of a gene : the regulatory region and the coding region -- 2.2 Mutations -- 2.3 Carcinogenic agents -- 2.4 DNA repair and predispositions to cancer -- Therapeutic strategies -- 2.5 Conventional therapies : chemotherapy and radiation therapy -- 2.6 Strategies that target DNS repair pathways -- 3 Regulation of gene expression -- 3.1 Transcription factors and transcriptional regulation -- 3.2 Chromatin structure -- 3.3 Epigenetic regulation of transcription -- 3.4 Evidence of a role for epigenetics in carcinogenesis -- 3.5 long non-coding RNAs -- 3.6 MicroRNAs (miRNAs) and regulation of mRNA expression -- 3.7 Telomeres and telomerase -- Therapeutic strategies -- 3.8 Epigenomic and histonomic drugs -- 3.9 Non-coding RNAs for diagnosis -- 3.10 Telomerase inhibitors -- 4 Growth factor signaling and oncogenes -- 4.1 Epidermal growth factors signaling: an important paradigm -- 4.2 Oncogenes -- Therapeutic strategies -- 4.3 Kinases as drug targets -- 5 The cell cycle -- 5.1 Cyclins and cyclin-dependent kinases (cdks) -- 5.2 Mechanisms of cdk regulation -- 5.3 Progression through the G1 checkpoint -- 5.4 The G2 checkpoint -- 5.5 The mitotic checkpoint -- 5.6 The cell cycle and cancer -- Therapeutic cancer -- 5.7 Cyclin-dependent kinase inhibitors -- 5.8 Other cell cycle kinase targets -- 5.9 Inhibitors of the mitotic spindle -- 6 Growth inhibitor and tumor suppressor genes -- 6.1 Definitions of tumor suppressor genes -- 6.2 The retinoblastoma gene -- 6.3 Mutations in the RB pathway and cancer -- 6.4 The p53 pathway -- 6.5 Mutations in the p53 pathway and cancer -- 6.6 Interaction of DNA viral protein products with RB and p53 -- Therapeutic strategies -- 6.7 Targeting of the p53 pathway -- 7 Apoptosis -- 7.1 Molecular mechanisms of apoptosis -- 7.2 Apoptosis and cancer -- 7.3 Apoptosis and chemotherapy -- 7.4 Apoptotic drugs -- 8 Cancer stem cells and the regulation of self-renewal and differentiation pathways : focus on colon cancer and leukemias -- 8.1 Cancer stem cells -- 8.2 The regulation of differentiation by gene expression -- Therapeutic strategies -- 8.3 Inhibitors of the Wnt pathway -- 8.4 Inhibitors of the Hh pathway -- 8.5 Inhibitors of PcG proteins -- 8.6 Leukemia and differentiation therapies -- 9 Metastasis -- 9.1 How do tumors spread? -- 9.2 The process of metastasis -- 9.3 Invasion and the epithelial-mesenchymal transition -- 9.4 Intravasation -- 9.5 Transport -- 9.6 Extravasation -- 9.7 Metastatic colonization -- Therapeutic strategies -- 9.8 Metalloproteinase inhibitors (MPIs) -- 9.9 Strategies for restoring metastasis suppressors -- 9.10 Targeting several steps of metastasis at once -- 10 Angiogenesis -- 10.1 The angiogenic switch -- 10.2 Cell behavior during angiogenic sprouting -- 10.3 Other means of tumor neovascularization -- Therapeutic strategies -- 10.4 Anti-angiogenic therapy -- 10.5 Vascular targeting by vascular disrupting agents -- 11 Nutrient and hormone effects on the genome -- 11.1 Introduction to food and cancer -- 11.2 Causative factors -- 11.3 Preventative factors : microconstituents of fruits and vegetables -- 11.4 Reprogramming energy metabolism in tumor cells -- an emerging hallmark of cancer -- 11.5 Genetic polymorphisms and diet -- 11.6 Vitamin D : a link between nutrients and hormone action -- 11.7 Hormones and cancer -- Therapeutic strategies -- 11.8 "Enhanced" foods and dietary supplements for chemoprevention -- 11.9 Drugs that target energy pathways -- 11.10 Drugs that target energy pathways -- 11.10 Drugs that target estrogen -- 12 Tumor immunology and immunotherapy -- 12.1 Lymphocytes : B cells and T cells -- 12.2 The tumor suppressive roles of the immune system -- 12.3 Immune checkpoints -- 12.4 Cancer immunoediting and tumor promotion -- 12.5 Mechanisms of avoiding immune destruction -- Therapeutic strategies -- 12.6 Therapeutic antibodies -- 12.7 Cancer vaccines -- 12.8 Immune checkpoints blockades -- 12.9 Adoptive T-cell transfer, modified T-cell receptors, and chimeric antigen receptors -- 12.10 Oncolytic viruses and virotherapy -- 13 Infectious agents and inflammation -- 13.1 Identifying infectious agents as carcinogens -- 13.2 Inflammation and cancer -- Therapeutic strategies -- 13.3 A national vaccination program against hepatitis B virus in Taiwan -- 13.4 Eradication of H. pylori and the relationship to prevention of gastric cancer -- 13.5 Cancer vaccines to prevent cervical cancer -- 13.6 Inhibition of inflammation -- 14 Technology and drug and diagnostics development -- 14.1 Microarrays and gene expression profiling -- 14.2 Analysis of biomarkers for diagnostics and prognostics -- 14.3 Studying gene function by CRISPR-Cas9 -- 14.4 Imaging -- 14.5 Cancer nanotechnology -- 14.6 Strategies of drug development -- 14.7 Development of imatinib -- 14.8 Second- and third-generation therapeutics -- 14.9 Improved clinical trial design -- 14.10 Personalized medicine and bioinformatics -- 14.11 Are we making progress? -- Appendix 1 : Cell cycle regulation -- Glossary -- Index. |
| Summary |
"The most engaging and accessible account of cancer biology that makes the link between our understanding of cancer and the development of new therapeutics crystal clear. -- Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics offers an engaging and manageable route into the complex subject of cancer biology. Using the hallmarks of cancer as a foundation, the book describes the cellular and molecular mechanisms underpinning the transformation of healthy cells into cancer cells. -- after discussing a specific biological hallmark of cancer, each chapter shows how this knowledge can be directly applied to the development of new targeted therapies, giving you a clear appreciation of how the theory translated to tackling the disease. The new edition gives a contemporary account of the field, drawing on the latest research but presenting it in a manner that you will find easy to understand. -- New to this edition: *New full colour diagrams help you visualize key concepts more effectively *Separate chapters for growing areas of cancer biology: Metastasis, Angiogenesis, Infectious Agents and Inflammation, and Technology and Drug and Diagnostics Development *Coverage of range of new topics, including immune checkpoints, studying gene function by CRISPR-Ca9, newly proposed mechanisms for the role of obesity in cancer, non-coding RNAs, and the role of exosomes in intercellular communication *Latest details of newly approved therapeutics" -- from back of book |
| Subject |
Cancer -- Molecular aspects
|
|
Cancer cells
|
| ISBN |
9780198717348 |
|
