| Description |
x, 318 p. : ill. ; 24 cm. |
| Series |
Methods in molecular medicine ; 25
|
| Bibliography |
Includes bibliographical references and index. |
| Contents |
Pt.1. Strategies -- Chemical construction of immunotoxins -- Construction of ribonuclease-antibody conjugates for selective cytotoxicity -- Intracellular targeting using bispecific antibodies -- Antibody conjugation methods for active targeting of liposomes -- Folate as a targeting device for proteins utilizing folate receptor-mediated endocytosis -- Preparation of recombinant RNase single-chain antibody fusion proteins -- Pt.2. Theoretical aspects -- Practical considerations in the exploitation of passive tumor targeting -- Effect of dose, molecular size, and binding affinity on uptake of antibodies -- Inhibition of tumor blood flow -- Pt.3. Applications -- Targeting in myocardial infarction -- Targeting HIV-infected cells -- Making fusion toxins to targetleukemia and lymphoma -- Antibody-bearing liposomes as chloroquine vehicles in treatment of murine malaria -- Immunotargeting of catalase to the pulmonary vascular endothelium -- Targeted gene transfer: a practical guide based on experience with lipid-based plasmid delivery systems |
| Subject |
Drug delivery systems
|
|
Drug carriers (Pharmacy)
|
| Added Author |
Francis, G. E
|
|
Delgado, Cristina
|
| ISBN |
089603531X (alk. paper) |
|
